Objective To investigate the effects of low-frequency neuromuscular electrical stimulation (NMES) combined with intermittent pneumatic compression (IPC) on lower limb motor function, limb edema and deep vein thrombosis (DVT) in patients with post-stroke hemiplegia. Methods A total of 92 patients with post-stroke hemiplegia who were admitted to the Department of Neurology at Zhoukou Central Hospital from January 2025 to January 2026 were selected as the subjects of this study. They were randomly divided into the control group and the combined group. Eventually, 44 cases in each group completed the intervention and follow-up.Moreover, both groups receive conventional treatment and rehabilitation training, the control group was added with IPC, and the combined group was added with NMES, and the course of treatment was 4 weeks. The lower limb motor function [Fugl-Meyer assessment of lower extremity (FMA-LE) scale], Berg balance scale (BBS), and Barthel index (BI) were evaluated before and after the intervention respectively. At the same time, the difference in circumference between the affected limb and the corresponding part on the healthy side, as well as the serum level of D-dimer (D-D) were assessed. The occurrence of DVT during the follow-up period and the related adverse reactions during treatment were recorded. Results After 4 weeks of intervention, FMA-LE, BBS and BI scores in the combined group were higher than those in the control group (all P＜0.001), and the difference of limb circumference was less than that in the control group (P＜0.01). The occurrence of DVT and and the D-dimer level in the combined group were lower than that in the control group (all P＜0.05). There were no serious adverse events in either group. Conclusion Low-frequency NMES combined with IPC can significantly improve lower limb motor function, reduce limb edema and reduce the risk of DVT.