基于CDFI 定量参数分析保胎灵胶囊联合地屈孕酮对早孕期患者子宫内膜容受性的影响
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沁阳市妇幼保健院

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Analysis of the effects of Baotailing Capsules combined with dydrogesterone on endometrial receptivity in patients in early pregnancy based on CDFI quantitative parameters
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Biyang County Maternal and Child Health and Family Planning Service Center

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    摘要:

    目的 探讨保胎灵胶囊联合地屈孕酮对早孕期患者子宫内膜容受性(endometrial receptivity,ER)的影响,并基于彩色多普勒血流成像(color doppler flow imaging,CDFI)定量参数分析其对血流动力学参数的改善作用。方法 选取2022年2月至2025年2月沁阳市妇幼保健院收治的86例先兆流产(threatened abortion,TA)与复发性流产(recurrent abortion,RA)患者,随机数字表法分为观察组(保胎灵胶囊+地屈孕酮,43例)与对照组(单用地屈孕酮,43例)。比较两组治疗前、治疗4周、治疗8周的CDFI定量参数[子宫内膜厚度、Salle评分、子宫螺旋动脉搏动指数(pulsatility index,PI)、阻力指数(resistance index,RI)及收缩期峰值流速(peak systolic velocity,PSV)],并比较两组治疗8周的血清孕酮(progesterone,P)、β-人绒毛膜促性腺激素(β-human chorionic gonadotropin,β-hCG)、血管内皮生长因子(vascular endothelial growth factor,VEGF)水平及妊娠结局(持续妊娠率)。随访至孕12周。结果 治疗后4周、8周,两组患者子宫内膜厚度、Salle评分、PI、RI、PSV较治疗前均显著改善(均P<0.05);观察组治疗8周内膜厚度、Salle评分≥3分占比、PI、RI、PSV改善幅度均显著优于对照组(均P<0.05)。治疗8周,观察组血清P、β-hCG、VEGF水平及持续妊娠率均显著高于对照组(均P<0.05)。结论 保胎灵胶囊联合地屈孕酮可有效改善早孕期患者子宫内膜血流灌注,优化ER;CDFI定量参数可作为评估ER及联合方案疗效的无创客观指标,在基层中医妇科保胎诊疗中具有实用价值。

    Abstract:

    Objective To investigate the effects of Baotailing Capsules combined with dindroprogesterone on endometrial receptivity (ER) in early pregnancy patients, and to analyze its improvement of hemodynamic parameters based on color doppler flow imaging (CDFI) quantitative parameters. Methods 86 cases of threatened abortion (TA) and recurrent abortion (RA) patients admitted to Qinyang Maternal and Child Health Hospital from February 2022 to February 2025 were selected and randomly divided into the observation group (taking Baotailing Capsules+diethylprogesterone, 43 cases) and the control group (taking diethylprogesterone alone, 43 cases) using the random number table method. The CDFI quantitative parameters [endometrial thickness, Salle score, uterine spiral artery pulsatility index (PI), resistance index (RI) and peak systolic velocity (PSV)] were compared between the two groups before treatment, at 4 weeks of treatment and at 8 weeks of treatment. And the levels of serum progesterone (P), β -human chorionic gonadotropin (β-hCG), vascular endothelial growth factor (VEGF) and the pregnancy outcomes (continuous pregnancy rate) of the two groups were compared after 8 weeks of treatment. Patients were followed up to 12 weeks of pregnancy. Results At 4 weeks and 8 weeks after treatment, the endometrial thickness, Salle score, PI, RI, and PSV of the patients in both groups were significantly improved compared with those before treatment (all P<0.05). The improvement in endometrial thickness, the proportion of patients with Salle score ≥3 points, PI, RI, and PSV within 8 weeks of treatment was significantly better in the observation group compared to the control group (all P<0.05). After 8 weeks of treatment, the levels of serum P, β-hCG and VEGF in the observation group, as well as the rate of continuous pregnancy, were significantly higher than those in the control group (all P<0.05). Conclusion Baotailing Capsules combined with desprogesterone can effectively improve endometrial blood flow perfusion in early pregnancy patients and optimize ER. The quantitative parameters of CDFI can be used as non-invasive and objective indicators for evaluating ER and the efficacy of the combined treatment, and have practical value in the gynecological pregnancy preservation treatment of traditional Chinese medicine at the grassroots level.

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张改红.基于CDFI 定量参数分析保胎灵胶囊联合地屈孕酮对早孕期患者子宫内膜容受性的影响[J].生物医学工程学进展,2026,(4):76-79

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  • 收稿日期:2026-07-22
  • 最后修改日期:2026-09-10
  • 录用日期:2026-09-10
  • 在线发布日期: 2026-10-20
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