尿动力学参数对良性前列腺增生合并下尿路症状患者膀胱出口梗阻的诊断价值
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新疆生产建设兵团医院

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新疆生产建设兵团医院2025年度院级科技计划项目(2025013)。


The diagnostic value of urodynamic parameters for bladder outlet obstruction in patients with benign prostatic hyperplasia and lower urinary tract symptoms
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Xinjiang Production and Construction Corps Hospital

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    摘要:

    目的 探讨尿动力学参数对良性前列腺增生(benign prostatic hyperplasia,BPH)合并下尿路症状(lower urinary tract symptoms,LUTS)患者膀胱出口梗阻(bladder outlet obstruction,BOO)的诊断价值。方法 回顾性收集新疆生产建设兵团医院泌尿外科2023年1月至2025年12月收治的150例BPH合并LUTS患者的临床资料。依据临床综合评估结果,并结合术后随访反应确定BOO结局,将患者分为BOO组和非BOO组。比较两组尿动力学参数的差异。采用Spearman相关分析评价主要尿动力学指标与BOO结局的关系,并通过受试者工作特征(receiver operating characteristic,ROC)曲线评估各指标及其联用的诊断效能。结果 两组患者年龄、体重指数(body mass index,BMI)、病程、前列腺特异性抗原(prostate specific antigen,PSA)水平及前列腺体积比较差异均无统计学意义(均P>0.05)。与非BOO 组相比,BOO 组最大逼尿肌压力(maximum detrusor pressure, P_detmax)和最大尿流率时逼尿肌压力(detrusor pressure at maximum flow,P_detQ_max)均较高(均P<0.05),最大尿流率(maximum flow rate,Q_max)较低(P<0.05)。P_detQ_max与BOO 结局呈正相关(P<0.05),Q_max与BOO 结局呈负相关(P<0.05)。ROC曲线分析显示,P_detQ_max的单项诊断效能较好;与Q_max联合后,BOO诊断效能进一步提高。结论 尿动力学压力-流率参数可为BPH合并LUTS患者BOO的评估提供客观参考。P_detQ_max具有较好的单项诊断价值,联合Q_max可提高诊断效能,有助于患者的临床分层和个体化治疗决策。

    Abstract:

    Objective To explore the diagnostic value of urodynamic parameters for bladder outlet obstruction (BOO) in patients with benign prostatic hyperplasia (BPH) combined with lower urinary tract symptoms (LUTS). Methods Clinical data were retrospectively collected from 150 patients with BPH-associated LUTS who were treated in the Department of Urology, Xinjiang Production and Construction Corps Hospital, from January 2023 to December 2025. Patients were assigned to the BOO or non-BOO group according to comprehensive clinical assessment, supplemented by postoperative follow-up findings. Urodynamic parameters were compared between the two groups. Spearman correlation analysis was used to assess the associations between key urodynamic variables and BOO status. Receiver operating characteristic (ROC) curves were constructed to evaluate the diagnostic performance of individual parameters and their combination. Results There were no significant differences in age, body mass index (BMI), disease duration, prostate specific antigen (PSA) level, or prostate volume between the two groups (all P>0.05). Compared with the non-BOO group, the BOO group showed higher maximum detrusor pressure (P_detmax) and detrusor pressure at maximum flow (P_detQ_max), together with a lower maximum urinary flow rate (Q_max) (all P<0.05). P_detQ_max was positively correlated with BOO status (P<0.05), whereas Q_max was negatively correlated with BOO status (P<0.05). ROC analysis showed that P_detQ_max had good diagnostic performance as a single parameter. Its diagnostic performance improved further when combined with Q_max. Conclusion Pressure-flow urodynamic parameters provide objective information for evaluating BOO in patients with BPH and LUTS. P_detQ_max has favorable individual diagnostic value, and its combination with Q_max may improve the diagnostic performance of BOO and support clinical stratification and individualized treatment decisions.

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王文莉.尿动力学参数对良性前列腺增生合并下尿路症状患者膀胱出口梗阻的诊断价值[J].生物医学工程学进展,2026,(3):214-218

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  • 收稿日期:2026-05-05
  • 最后修改日期:2026-06-26
  • 录用日期:2026-06-26
  • 在线发布日期: 2026-08-19
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