Objective To explore the application effect of an information-based prescription review model in promoting the rational use of antibiotics in the pediatric outpatient, and to provide a basis for the standardized clinical application of antibiotics in pediatrics. Methods A total of 382 cases involving antibiotic use in the pediatric outpatient department of the 988th Hospital of the Joint Logistics Support Force from July 2024 to July 2025 were selected as the study subjects. Among them, 191 cases from July 2024 to December 2024 were assigned to the control group (pre-intervention, traditional manual prescription review), and 191 cases from January 2025 to July 2025 were assigned to the intervention group (post-intervention, information-based prescription review model). In the information-based evaluation model for prescription review, in addition to verifying the site of infection and medication indications, the focus is on examining whether antimicrobial agents are selected based on pathogenetic test results or regional epidemiological data. Interventions are implemented for prescriptions involving broad-spectrum antimicrobial use without pathogenetic justification or those with unclear targeting specificity. The types of diseases and medications, the distribution of irrational medication types, and the rational use rate of antibiotics were compared between the two groups. Results The rational use rate of antibiotics in the intervention group was significantly higher than that in the control group (P＜0.05), the incidence rates of various types of irrational medication, such as unclear medication indications, improper dosage, unreasonable dosing frequency, and inappropriate combination use, were all lower in the intervention group compared to the control group (all P＜0.05). Conclusion The information-based prescription review model can effectively improve the rational use rate of antibiotics in pediatric outpatient clinics and reduce irrational medication use. Compared with the traditional manual review model, it offers advantages such as higher efficiency, greater precision, and traceability, making it worthy of promotion and application in the clinical management of antibiotics in pediatric outpatient settings.