Objective To assess the efficacy of Xiaoyin capsules combined with calcipotriol ointment in patients with bloodheat and wind-dryness type psoriasis vulgaris. Methods A total of 80 patients diagnosed with blood-heat and wind-dryness subtype of psoriasis vulgaris, who were consecutively admitted to the Department of Dermatology of Tongzhou Integrated Traditional Chinese and Western Medicine Hospital from December 2025 to March 2026, were enrolled in this study. Patients were allocated 1 vs. 1 to the treatment group and the control group (40 cases per group) using a stratified block randomization method. Patients in the control group received topical treatment with calcipotriol ointment alone, while those in the treatment group were administered oral Xiaoyin capsules combined with the same topical calcipotriol ointment intervention. The treatment course for both groups lasted 8 weeks. The changes in psoriasis area and severity index (PASI) score, the percentage of involved body surface area (BSA), and traditional chinese medicine (TCM) syndrome score before and after treatment were observed in both groups. The incidence of adverse events during the treatment period was also compared between the two groups. Results At 2, 4 and 8 weeks of treatment, the PASI scores in both groups were significantly decreased compared with those before treatment (all P＜0.05). At 4 and 8 weeks of treatment, the PASI scores of the treatment group were significantly lower than those of the control group at the same time points (all P＜0.05). After 8 weeks of treatment, the percentage of involved BSA in the treatment group was significantly lower than that before treatment in the same group (P＜0.05), and the difference was statistically significant when compared with the control group (P＜0.05). After 8 weeks of treatment, the individual symptom scores of skin erythema, scaling degree, pruritus severity and skin dryness, as well as the total TCM syndrome score in the treatment group, were all significantly lower than those before treatment in the same group (all P＜0.05). Moreover, all the above indexes in the treatment group were significantly lower than those in the control group (all P＜0.05). The adverse reactions in both groups were mild, did not interfere with the treatment process, and no severe adverse events occurred. There was no statistically significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion Xiaoyin capsules combined with calcipotriol ointment can improve skin lesions and TCM syndrome manifestations in blood-heat and wind-dryness type psoriasis vulgaris.