Objective To assess the impact of a collaborative, seamless, full-cycle care model on the psychological state and nursing safety incidents of patients undergoing digestive endoscopic procedures. Methods A prospective randomized controlled design was employed to assign 210 patients admitted from December 2020 to December 2024 into a control group (receiving routine care) and an observation group (receiving collaborative care), with 105 patients in each group. Psychological status, treatment adherence, and health literacy were respectively assessed by using Hamilton anxiety scale (HAMA), Hamilton depression scale (HAMD), perceived stress scale (PSS), Morisky medication adherence scale-8 (MMAS-8), Knowledge, Attitudes, and Practices (KAP) questionnaires. Nursing safety incidents were also documented. Results Following intervention, the observation group exhibited significantly lower scores of HAMA, HAMD, PSS compared to the control group (all P＜0.001); However, the MMAS-8 score was significantly higher in the observation group compared to the control group (P < 0.001). The incidence of nursing safety events was significantly lower in the observation group than in the control group (9.52% vs. 19.05%, P＜0.05), and KAP scores showed a significant increase (P＜0.001). Conclusion The collaborative and seamless care model implemented throughout the entire treatment period can effectively improve the mental health of patients undergoing digestive endoscopy treatment, reduce the incidence of adverse care events, and enhance health literacy and treatment compliance.