Objective To investigate the effect of “Internet Plus” combined with hospital-to-home (H2H) nutritional management in patients with ovarian cancer during the peri-chemotherapy period. Methods A total of 62 patients with ovarian cancer who were scheduled to undergo the first cycle of chemotherapy and were admitted to Zhengzhou Central Hospital Affiliated to Zhengzhou University from November 2024 to April 2025 were included. Patients in the Gynecological Ward I were assigned to the intervention group (31 cases, standard care plan + "Internet Plus" combined with H2H nutrition management plan), while those in the Gynecological Ward II were assigned to the control group (31 cases, standard care plan). The body mass index (BMI), laboratory indicators [serum albumin (ALB), prealbumin (PA), hemoglobin (Hb)], patient-generated subjective global assessment (PG-SGA) score, incidence of malnutrition, gastrointestinal symptom rating scale (GSRS) score, and EORTC quality of life questionnaire-core 30 (QLQ-C30) score were compared between the two groups before intervention, at 1 month and 3 months after intervention. Results At 3 months after intervention, the BMI, Alb, PA, Hb, overall health and function scores of the QLQ-C30 scale in the intervention group were all higher than those in the control group (all P＜0.05). The PG-SGA score, each dimension score of GSRS, the incidence of malnutrition, and the symptom dimension score of QLQ-C30 in the intervention group were all lower than those in the control group (All P＜0.05). Conclusion Integrating “Internet Plus”with H2H nutritional management demonstrates efficacy in enhancing nutritional status, alleviating gastrointestinal dysfunction, and improving the quality of life for patients with ovarian cancer during the peri-chemotherapy period.