Objective To explore the effects of early functional exercise combined with elastic stocking intervention on lower limb swelling relief, quality of life, and nursing satisfaction in patients undergoing interventional therapy for lower extremity deep vein thrombosis (LEDVT). Methods Sixty patients with LEDVT who underwent interventional therapy in the Interventional Department of Xuzhou Mining Group General Hospital from January to December 2024 were selected and randomly divided into a control group (receiving routine care) and an observation group (receiving early functional exercise combined with elastic stocking intervention on the basis of routine care), 30 cases in each group. The postoperative lower limb swelling, 36-item short form health survey (SF-36) quality of life scores, complication rates, and nursing satisfaction were compared between the two groups. Results At 1 week, 3 and 6 months postoperatively, the postoperative lower limb circumference differences in the observation group were significantly lower than those in the control group (all P＜0.05). At 3 and 6 months postoperatively, the SF-36 dimensions and total scores in the observation group were significantly higher than those in the control group (all P＜0.05), the total complication rate was lower than that in the control group (P＜0.05), and the satisfaction score was significantly higher than that in the control group (P＜0.05). Conclusion Early functional exercise combined with elastic stocking intervention after LEDVT interventional therapy can effectively alleviate lower limb swelling, improve quality of life, reduce complication rates, and enhance nursing satisfaction.