Objective To observe the therapeutic effect of Montelukast combined with Primecorisol inhalant on children with bronchiolitis and the effect on TNF-α and IL-10. Methods A total of 80 children with bronchiolitis admitted to our hospital from January 2019 to February 2022 were selected and divided into observation group and control group according to numerical randomization method, with 40 cases in each group. The control group was only treated with montelukast, while the observation group was treated with Pulmicort Respules inhalation on the basis of the control group. The excellent and good rate of treatment effect, arterial partial pressure of oxygen and TNF in the two groups before and after treatment were compared-α The improvement of index level, IL-10 index level and the time of disappearance of symptoms were compared and analyzed. Results The rate of good and good effect in observation group was significantly higher than that in control group (P ＜ 0.05). There was no significant difference between the observation group and the control group before treatment, but after treatment, the levels of arterial blood oxygen partial pressure, TNF-α index and IL-10 index were significantly improved, and the improvement level in the observation group was significantly better than that in the control group (P ＜ 0.05). The time of symptom resolution in observation group was significantly shorter than that in control group (P ＜ 0.05). Conclusion Montelukast Combined with Pulmicort Respules inhalation has good curative effect in the treatment of children with bronchiolitis, which is more conducive to promoting TNF in children-α The improvement of the index level and IL-10 index level can shorten the time for the patients’ symptoms to subside.